Development of a safe vaccine against disease in commercially farmed catfish, aiming to reduce antibiotic use and mortality in pangasius (Pangasius sp) in the Mekong Delta through the development of injectable, impregnated vaccines and feeding to prevent pathogens from fry to grow-out. To make the industrial catfish fishery more sustainable, fish are immunized against bacterial disease outbreaks, improving the environment and reducing the pressure of trade barriers.